Negative regulation of triglyceride metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of triglyceride metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP4, HSPD1, and ADORA2B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP4 grouped by Negative regulation of triglyceride metabolic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MAP4 →	-1.168	-1.574	.005	.002	3	6
KIDNEY	HSPD1 →	+0.689	+1.126	.003	.002	3	5
CNS	ADORA2B →	-0.954	-0.963	.002	<.001	3	5
KIDNEY	MRPL3 →	+0.484	+0.894	<.001	.003	3	4
LUNG_SCLC	RHPN1 →	+1.776	+1.130	.008	.002	3	4
LUNG_SCLC	ZNF891 →	+0.797	+0.885	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP4 by Negative regulation of triglyceride metabolic process activity — URINARY_TRACT

Explore this box plot interactively →