Negative regulation of triglyceride metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of triglyceride metabolic process pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 14 member genes.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher Negative regulation of triglyceride metabolic process pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LIHC and LUAD, show the opposite pattern, with higher activity associated with better survival.

LIHC, LUAD, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.811	0.588	<.001	77	view →
LUAD	DFS	Tertile	All	0.431	0.255	.006	50	view →
LGG	OS	Median	All	0.885	0.755	<.001	41	view →
READ	OS	Median	III,IV	0.677	1.000	.001	34	view →
SKCM	OS	Median	III,IV	0.527	0.244	.002	25	view →
ACC	OS	Median	II,III,IV	1.000	0.700	.004	22	view →
MESO	OS	Median	II,III,IV	0.262	0.668	.001	18	view →
PRAD	DFS	Median	All	0.531	0.857	.006	12	view →
CHOL	DFS	Median	All	0.123	0.620	.009	12	view →
KIRC	DFS	Quartile	III,IV	0.863	0.696	.015	10	view →
SCLC	DFS	Tertile	All	0.715	0.438	.014	8	view →
UCS	OS	Quartile	II,III,IV	0.226	0.739	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0090209–LIHC (OS)

Open the LIHC breakdown →