Positive regulation of triglyceride metabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of triglyceride metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NOC2L, LIG3_S210, and NPM3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of triglyceride metabolic process activity versus NOC2L in LUAD (Pearson r = -0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NOC2L →	-0.262	-0.054	.003	<.001	3	5
BRCA	LIG3_S210 →	-1.153	-0.048	<.001	.004	3	4
BRCA	NPM3 →	-0.497	-0.054	<.001	<.001	3	4
COAD	AP2S1 →	+0.206	+0.040	.003	.001	3	4
LUAD	UIMC1_S653 →	-0.280	-0.042	<.001	<.001	3	4
LSCC	UAP1L1 →	+0.319	+0.045	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090208 vs NOC2L — LUAD

Explore this scatter interactively →