Positive regulation of triglyceride metabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of triglyceride metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OBI1-AS1, S100B, and CRACD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of triglyceride metabolic process activity versus OBI1-AS1 in BRCA (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OBI1-AS1 →	-0.030	-0.516	.001	.009	3	4
LUAD	S100B →	+1.167	+1.020	<.001	<.001	3	4
BRCA	CRACD →	-0.609	-0.543	.002	.001	3	3
BRCA	MINDY3 →	-0.534	-0.658	.006	<.001	3	3
BRCA	HAUS1P1 →	+0.209	+0.422	.009	.004	3	3
LUAD	CAV1 →	+0.930	+0.703	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090208 vs OBI1-AS1 — BRCA

Explore this scatter interactively →