Positive regulation of triglyceride metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of triglyceride metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPLD1, KCNJ11, and AADAC, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPLD1 grouped by Positive regulation of triglyceride metabolic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GPLD1 →	-0.409	-1.577	.003	.003	3	7
LUNG_NSCLC_LUAD	KCNJ11 →	-0.179	-1.094	<.001	<.001	3	6
LUNG_SCLC	AADAC →	-0.633	-1.196	<.001	.008	3	6
KIDNEY	RABL2A →	-0.237	-0.835	.003	.006	3	5
LUNG_NSCLC_LUSC	TSPO →	-0.345	-1.173	.009	.008	3	5
SKIN	RGN →	-0.182	-1.147	.006	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPLD1 by Positive regulation of triglyceride metabolic process activity — PANCREAS

Explore this box plot interactively →