Positive regulation of triglyceride metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of triglyceride metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAS2L1, RPL22, and BIN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GAS2L1 grouped by Positive regulation of triglyceride metabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GAS2L1 →	-0.901	-0.774	.003	.007	3	4
LUNG_SCLC	RPL22 →	-0.866	-1.072	.003	.005	3	3
UPPER_AERODIGESTIVE_TRACT	BIN1 →	-1.432	-0.754	<.001	.007	3	3
UPPER_AERODIGESTIVE_TRACT	CEP19 →	-0.933	-1.078	<.001	.008	3	3
UPPER_AERODIGESTIVE_TRACT	WDR25 →	-0.983	-1.011	.002	.007	3	3
UPPER_AERODIGESTIVE_TRACT	TOMM6 →	-0.872	-0.754	.004	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GAS2L1 by Positive regulation of triglyceride metabolic process activity — STOMACH

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