Negative regulation of release of cytochrome c from mitochondria

Across TCGA patient cohorts, RNA activity of the Negative regulation of release of cytochrome c from mitochondria pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRA2A_T202, CGGBP1, and SRRM2_S2426, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of release of cytochrome c from mitochondria activity versus TRA2A_T202 in LSCC (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRA2A_T202 →	-0.327	-0.092	<.001	<.001	3	6
GBM	CGGBP1 →	-0.395	-0.048	<.001	.001	3	6
OV	SRRM2_S2426 →	-1.458	-0.059	.008	.007	3	5
GBM	UPP1 →	+0.705	+0.055	<.001	<.001	3	5
LSCC	NOL3 →	+0.617	+0.079	<.001	<.001	3	5
GBM	NOL3_T114 →	+0.668	+0.061	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090201 vs TRA2A_T202 — LSCC

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