Negative regulation of release of cytochrome c from mitochondria

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of release of cytochrome c from mitochondria pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 20 member genes.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher Negative regulation of release of cytochrome c from mitochondria pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and CHOL, show the opposite pattern, with higher activity associated with better survival.

COAD, MESO, and LIHC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	All	0.825	0.916	<.001	81	view →
MESO	DFS	Median	II,III,IV	0.271	0.471	.001	69	view →
LIHC	OS	Median	III,IV	0.306	0.702	<.001	62	view →
ACC	DFS	Tertile	All	0.345	0.732	<.001	61	view →
SCLC	OS	Median	II,III,IV	0.421	1.000	.002	41	view →
LGG	DFS	Median	All	0.785	0.869	<.001	38	view →
KIRC	DFS	Quartile	All	0.462	0.708	<.001	36	view →
THCA	DFS	Median	III,IV	0.591	0.795	.004	33	view →
PAAD	OS	Quartile	All	0.408	0.763	.001	26	view →
READ	OS	Median	IV	0.687	1.000	.004	24	view →
PRAD	DFS	Tertile	All	0.748	0.913	.003	18	view →
HNSC	DFS	Median	IV	0.714	0.580	.023	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0090201–COAD (OS)

Open the COAD breakdown →