Negative regulation of release of cytochrome c from mitochondria

Across TCGA cell cohorts, RNA activity of the Negative regulation of release of cytochrome c from mitochondria pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOAT1, CAVIN1, and SOCS5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of release of cytochrome c from mitochondria activity versus SOAT1 in BREAST (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SOAT1 →	-1.895	-0.412	<.001	<.001	3	5
BLOOD_Leukemia	CAVIN1 →	+2.459	+0.809	.001	.002	3	4
BREAST	SOCS5 →	-0.749	-0.409	.002	.004	3	4
CNS	ZMYND10 →	+0.765	+0.697	.006	.005	3	3
PANCREAS	ZNF232 →	-0.873	-0.356	<.001	<.001	3	3
STOMACH	RAB17 →	+2.810	+0.725	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090201 vs SOAT1 — BREAST

Explore this scatter interactively →