Regulation of cholesterol metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of cholesterol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VRK1, SMC4, and KIF14, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cholesterol metabolic process activity versus VRK1 in LSCC (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	VRK1 →	-0.672	-0.285	.001	.001	3	7
HNSC	SMC4 →	-0.680	-0.153	.001	<.001	3	6
GBM	KIF14 →	-1.013	-0.199	<.001	<.001	3	6
BRCA	BRIP1 →	-0.652	-0.183	<.001	<.001	3	6
LSCC	CEP78 →	-0.515	-0.195	.003	.008	3	6
GBM	RACGAP1 →	-0.686	-0.172	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090181 vs VRK1 — LSCC

Explore this scatter interactively →