Establishment of epithelial cell polarity

Across TCGA patient cohorts, RNA activity of the Establishment of epithelial cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRHL3-AS1, GAPDHP49, and NEBL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of epithelial cell polarity activity versus GRHL3-AS1 in OV (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GRHL3-AS1 →	+0.596	+0.693	<.001	.004	3	4
LUAD	GAPDHP49 →	+0.771	+0.546	.004	.004	3	4
CCRCC	NEBL →	+0.712	+0.922	<.001	<.001	3	4
GBM	STYXL2 →	+0.419	+0.427	.006	.005	3	4
PDAC	MTND3P5 →	-0.158	-0.484	.001	.004	3	3
LUAD	TMPRSS13 →	+0.638	+0.376	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090162 vs GRHL3-AS1 — OV

Explore this scatter interactively →