Establishment of epithelial cell polarity

Across TCGA pan-cancer cohorts, RNA activity of the Establishment of epithelial cell polarity pathway differs between tumor and matched normal tissue in 11 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KIRC and KICH, show the opposite pattern, with lower activity in tumor tissue.

COAD, KIRC, and KICH show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
COAD	Female	All	+0.042	<.001	11	view →
KIRC	Male	II,III,IV	−0.025	<.001	8	view →
KICH	Female	II,III,IV	−0.054	<.001	6	view →
THCA	Female	All	−0.035	<.001	5	view →
BRCA	Female	All	−0.017	.008	5	view →
LIHC	All	All	+0.013	.006	5	view →
CHOL	Male	All	+0.078	<.001	3	view →
LUSC	All	All	−0.018	.002	3	view →
PAAD	All	All	+0.047	.040	2	view →
KIRP	All	IV	+0.032	.048	2	view →
ESCA	Female	All	−0.056	.022	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 11 strongest of 11 lineages.

GO:0090162–COAD

Open the COAD breakdown →