Epithelial cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Epithelial cell-cell adhesion pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOHLH1, ZNF141, and PDLIM4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SOHLH1 grouped by Epithelial cell-cell adhesion-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SOHLH1 →	+0.240	+0.166	.007	.003	3	5
LUNG_SCLC	ZNF141 →	+0.210	+0.198	<.001	<.001	3	4
CNS	PDLIM4 →	-0.242	-0.169	.004	.005	3	4
PANCREAS	OR2AK2 →	-0.214	-0.141	<.001	.001	3	4
BONE	SOX11 →	-0.215	-0.265	.006	.004	3	4
SOFT_TISSUE	SERPINB10 →	-0.158	-0.194	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SOHLH1 by Epithelial cell-cell adhesion activity — OVARY

Explore this box plot interactively →