Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GEM, ITGA11, and AKT3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway activity versus GEM in UCEC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GEM →	+0.981	+0.174	.002	.005	3	6
CCRCC	ITGA11 →	+0.693	+0.312	<.001	<.001	3	6
UCEC	AKT3 →	+0.902	+0.263	<.001	<.001	3	5
LSCC	CACNA2D1 →	+0.975	+0.389	<.001	.001	3	5
UCEC	JAM3 →	+0.507	+0.148	<.001	<.001	3	5
CCRCC	LINC00702 →	+0.379	+0.322	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090100 vs GEM — UCEC

Explore this scatter interactively →