Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway pathway differs between tumor and matched normal tissue in 14 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as COAD and LUAD, show the opposite pattern, with lower activity in tumor tissue.

COAD, LUAD, and BLCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
COAD	Female	All	−0.041	<.001	10	view →
LUAD	All	III,IV	−0.078	<.001	9	view →
BLCA	All	All	−0.043	<.001	9	view →
LUSC	Male	II,III,IV	−0.079	<.001	8	view →
THCA	All	II,III,IV	−0.034	<.001	8	view →
KICH	Female	All	−0.049	<.001	7	view →
KIRP	Male	All	−0.037	<.001	7	view →
UCEC	All	III,IV	−0.058	<.001	6	view →
BRCA	All	III,IV	−0.051	<.001	6	view →
KIRC	All	II,III,IV	−0.015	.001	6	view →
CHOL	All	All	+0.044	<.001	3	view →
READ	Female	All	−0.069	<.001	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 14 lineages.

GO:0090100–COAD

Open the COAD breakdown →