Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSRA, RPS4X, and SCAMP4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MSRA grouped by Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MSRA →	-0.961	-0.248	.001	<.001	3	4
BREAST	RPS4X →	+0.820	+0.217	<.001	<.001	3	4
OESOPHAGUS	SCAMP4 →	+0.738	+0.175	.002	.006	3	4
CNS	EIF2S3 →	+0.590	+0.208	<.001	.001	3	4
CNS	ADAP2 →	+0.384	+0.197	.004	.003	3	4
KIDNEY	ZNF408 →	+0.775	+0.249	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MSRA by Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway activity — SKIN

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