Foam cell differentiation

Across TCGA patient cohorts, RNA activity of the Foam cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NOC2L, XPO5, and S100B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Foam cell differentiation activity versus NOC2L in BRCA (Pearson r = -0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NOC2L →	-0.303	-0.032	<.001	<.001	3	8
LSCC	XPO5 →	-0.525	-0.062	.002	<.001	2	8
LUAD	S100B →	+1.217	+0.078	<.001	<.001	3	7
LSCC	SOX4_S354 →	-0.993	-0.075	.001	<.001	3	7
LUAD	TOP2A →	-0.755	-0.043	<.001	<.001	3	7
LUAD	UTP15 →	-0.263	-0.039	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090077 vs NOC2L — BRCA

Explore this scatter interactively →