Positive regulation of cell cycle process

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell cycle process pathway is significantly associated with the protein abundance of multiple proteins, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPC24, SF1, and NCAPD2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell cycle process activity versus SPC24 in BREAST (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SPC24 →	+0.901	+0.110	.002	.006	3	9
LUNG_SCLC	SF1 →	+0.537	+0.187	<.001	<.001	3	8
BREAST	NCAPD2 →	+0.906	+0.138	<.001	<.001	3	8
BREAST	SMC4 →	+0.760	+0.124	<.001	<.001	3	8
BONE	UBE2C →	+1.489	+0.153	<.001	.004	3	8
LUNG_SCLC	HADHB →	-1.353	-0.205	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090068 vs SPC24 — BREAST

Explore this scatter interactively →