Regulation of heart rate by cardiac conduction

Across TCGA patient cohorts, RNA activity of the Regulation of heart rate by cardiac conduction pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX41, ECT2_T359, and UTP25, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heart rate by cardiac conduction activity versus DDX41 in BRCA (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DDX41 →	-0.174	-0.034	<.001	<.001	3	6
LSCC	ECT2_T359 →	-0.923	-0.057	.001	<.001	3	6
BRCA	UTP25 →	-0.445	-0.037	<.001	<.001	3	6
PDAC	ADD1 →	+0.195	+0.037	<.001	<.001	3	6
BRCA	DHX9 →	-0.211	-0.036	<.001	<.001	3	6
GBM	TOP2A →	-0.802	-0.094	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086091 vs DDX41 — BRCA

Explore this scatter interactively →