Regulation of heart rate by cardiac conduction

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of heart rate by cardiac conduction pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 38 member genes.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher Regulation of heart rate by cardiac conduction pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and THCA, show the opposite pattern, with higher activity associated with better survival.

UCS, THCA, and DLBC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Quartile	II,III,IV	0.666	0.143	<.001	64	view →
THCA	OS	Median	II,III,IV	1.000	0.806	.008	48	view →
DLBC	OS	Median	IV	0.213	0.931	.001	33	view →
UCEC	DFS	Median	All	0.553	0.709	.006	26	view →
ESCA	DFS	Quartile	III,IV	0.598	0.257	<.001	24	view →
LUSC	OS	Median	III,IV	0.563	0.263	.003	24	view →
LIHC	OS	Median	All	0.686	0.848	<.001	23	view →
READ	DFS	Quartile	II,III,IV	0.556	0.912	.005	19	view →
THYM	OS	Tertile	All	0.719	0.979	.008	19	view →
OV	OS	Tertile	II,III,IV	0.404	0.299	.024	18	view →
KIRC	OS	Median	All	0.844	0.773	.016	16	view →
KIRP	OS	Median	III,IV	0.892	0.532	.006	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0086091–UCS (OS)

Open the UCS breakdown →