Membrane depolarization during AV node cell action potential

Across TCGA cell cohorts, RNA activity of the Membrane depolarization during AV node cell action potential pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP1, HMGA1, and RACK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DUSP1 grouped by Membrane depolarization during AV node cell action potential-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	DUSP1 →	+2.594	+1.614	.001	.002	3	5
LIVER	HMGA1 →	+1.045	+1.530	.001	<.001	3	4
SKIN	RACK1 →	+0.574	+1.122	.007	.003	3	4
OVARY	POPDC3 →	+1.948	+0.998	.002	.009	3	4
BLOOD_Leukemia	MAP3K20 →	+1.529	+0.976	.006	.007	2	5
OVARY	CFAP70 →	-0.750	-1.067	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DUSP1 by Membrane depolarization during AV node cell action potential activity — BLOOD_Myeloma

Explore this box plot interactively →