Membrane depolarization during AV node cell action potential

Across TCGA pan-cancer cohorts, RNA activity of the Membrane depolarization during AV node cell action potential pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Membrane depolarization during AV node cell action potential pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and UCS, show the opposite pattern, with higher activity associated with better survival.

KIRP, UCS, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.813	0.576	<.001	141	view →
UCS	DFS	Median	III,IV	0.464	0.124	.002	36	view →
KIRC	OS	Tertile	All	0.932	0.826	<.001	35	view →
UVM	OS	Quartile	All	0.587	0.933	.004	33	view →
PRAD	OS	Median	All	0.817	1.000	.001	32	view →
STAD	DFS	Median	IV	0.503	0.154	.008	28	view →
THYM	OS	Tertile	II,III,IV	0.836	1.000	.005	27	view →
SCLC	OS	Median	II,III,IV	0.422	0.710	.007	27	view →
LUAD	DFS	Quartile	All	0.734	0.854	.001	23	view →
READ	OS	Tertile	IV	0.574	0.959	.008	23	view →
ESCA	DFS	Median	II,III,IV	0.589	0.389	.005	21	view →
ACC	OS	Quartile	All	0.418	0.912	.006	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0086045–KIRP (OS)

Open the KIRP breakdown →