Cardiac muscle cell-cardiac muscle cell adhesion

Across TCGA cell cohorts, RNA activity of the Cardiac muscle cell-cardiac muscle cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MACIR, PIP4P2, and CIAO3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MACIR grouped by Cardiac muscle cell-cardiac muscle cell adhesion-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MACIR →	+0.932	+1.216	.002	<.001	3	5
BREAST	PIP4P2 →	-1.336	-1.153	.002	<.001	3	4
BREAST	CIAO3 →	+0.751	+1.000	.004	.002	3	4
BREAST	TRPS1 →	+2.515	+1.398	<.001	<.001	3	4
BREAST	ZNF552 →	+1.820	+1.411	<.001	<.001	3	4
BREAST	HSD17B11 →	-1.924	-1.195	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MACIR by Cardiac muscle cell-cardiac muscle cell adhesion activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →