Bundle of His cell to Purkinje myocyte signaling

Across TCGA patient cohorts, RNA activity of the Bundle of His cell to Purkinje myocyte signaling pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MACIR, H2BU1, and RNF223, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bundle of His cell to Purkinje myocyte signaling activity versus MACIR in BRCA (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MACIR →	+0.452	+0.360	.009	.008	3	3
COAD	H2BU1 →	+0.333	+0.635	.003	.003	3	2
COAD	RNF223 →	+0.469	+0.716	<.001	<.001	3	2
OV	GRHL2 →	+0.522	+0.230	.006	.008	3	2
CCRCC	GCDH →	-0.219	-0.491	.002	.008	3	2
BRCA	TCERG1 →	+0.308	+0.478	.008	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086028 vs MACIR — BRCA

Explore this scatter interactively →