Bundle of His cell to Purkinje myocyte signaling

Across TCGA cell cohorts, RNA activity of the Bundle of His cell to Purkinje myocyte signaling pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are METTL18, TIMM8B, and KATNA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, METTL18 grouped by Bundle of His cell to Purkinje myocyte signaling-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	METTL18 →	-0.801	-0.937	<.001	<.001	3	5
STOMACH	TIMM8B →	-0.738	-1.172	.001	.003	3	5
BLOOD_Leukemia	KATNA1 →	-0.768	-0.967	.003	.006	2	6
STOMACH	MLEC →	+1.625	+1.154	.001	.006	3	4
STOMACH	PKDCC →	+3.407	+0.931	.004	.004	3	4
UPPER_AERODIGESTIVE_TRACT	UGT8 →	-1.210	-1.327	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

METTL18 by Bundle of His cell to Purkinje myocyte signaling activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →