Membrane repolarization during cardiac muscle cell action potential

Across TCGA patient cohorts, RNA activity of the Membrane repolarization during cardiac muscle cell action potential pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARMC6, PABPN1_S95, and RNMT, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane repolarization during cardiac muscle cell action potential activity versus ARMC6 in LUAD (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ARMC6 →	-0.186	-0.038	.001	.004	3	6
PDAC	PABPN1_S95 →	-0.975	-0.043	.002	.002	3	5
GBM	RNMT →	-0.244	-0.069	<.001	<.001	3	5
GBM	KPNB1 →	-0.157	-0.056	<.001	.001	3	5
GBM	PRPF31 →	-0.233	-0.066	.003	.003	3	4
BRCA	SETDB1_S1066 →	-0.525	-0.033	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086013 vs ARMC6 — LUAD

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