Membrane repolarization during cardiac muscle cell action potential

Across TCGA pan-cancer cohorts, RNA activity of the Membrane repolarization during cardiac muscle cell action potential pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 24 member genes.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher Membrane repolarization during cardiac muscle cell action potential pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ACC and COAD, show the opposite pattern, with higher activity associated with better survival.

DLBC, ACC, and COAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Median	All	0.776	1.000	.002	75	view →
ACC	DFS	Median	All	0.660	0.284	<.001	69	view →
COAD	DFS	Quartile	All	0.668	0.317	.002	47	view →
THCA	DFS	Quartile	All	0.909	0.712	.001	44	view →
HNSC	DFS	Quartile	III,IV	0.124	0.365	.002	42	view →
OV	OS	Tertile	IV	0.283	0.598	.004	22	view →
CHOL	DFS	Quartile	All	0.137	0.793	.004	21	view →
SKCM	DFS	Median	All	0.779	0.700	.002	18	view →
THYM	OS	Median	All	0.910	1.000	.004	17	view →
MESO	OS	Median	All	0.488	0.287	.001	14	view →
LIHC	OS	Quartile	III,IV	1.000	0.420	.011	13	view →
ESCA	OS	Tertile	IV	0.743	0.393	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0086013–DLBC (OS)

Open the DLBC breakdown →