Cardiac muscle cell contraction

Across TCGA patient cohorts, RNA activity of the Cardiac muscle cell contraction pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLCA2, PLS3, and CRYAB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle cell contraction activity versus CLCA2 in LSCC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLCA2 →	+1.380	+0.264	.002	.007	3	4
BRCA	PLS3 →	+0.805	+0.611	<.001	<.001	3	4
BRCA	CRYAB →	+1.258	+0.669	.005	<.001	3	4
BRCA	GNAI1 →	+0.347	+0.429	.007	.001	3	4
UCEC	HEY2 →	+1.202	+0.802	.001	.001	3	4
CCRCC	TAGLN →	+1.242	+0.748	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086003 vs CLCA2 — LSCC

Explore this scatter interactively →