Cardiac muscle cell contraction

Across TCGA pan-cancer cohorts, RNA activity of the Cardiac muscle cell contraction pathway differs between tumor and matched normal tissue in 13 of the 18 cancer types tested.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as THCA and BLCA, show the opposite pattern, with lower activity in tumor tissue.

KIRC, THCA, and BLCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KIRC	Male	IV	+0.035	<.001	11	view →
THCA	Male	II,III,IV	−0.025	<.001	10	view →
BLCA	All	III,IV	−0.031	.008	7	view →
UCEC	All	III,IV	−0.060	<.001	6	view →
COAD	Male	II,III,IV	−0.028	.007	6	view →
BRCA	All	III,IV	−0.026	<.001	6	view →
LUSC	Male	All	−0.020	.002	4	view →
KIRP	Female	II,III,IV	−0.032	.005	3	view →
LIHC	Male	All	+0.015	.004	2	view →
PRAD	All	All	−0.011	.049	2	view →
CHOL	All	All	+0.027	.035	1	view →
HNSC	Female	All	+0.022	.043	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 13 lineages.

GO:0086003–KIRC

Open the KIRC breakdown →