Regulation of fertilization

Across TCGA patient cohorts, RNA activity of the Regulation of fertilization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLAT, ACTN1, and CALD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fertilization activity versus PLAT in LSCC (Pearson r = 0.70).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PLAT →	+0.810	+0.168	<.001	<.001	3	7
UCEC	ACTN1 →	+0.383	+0.077	.005	.007	3	7
UCEC	CALD1 →	+0.591	+0.063	.001	.006	3	6
GBM	MYH9 →	+0.398	+0.065	<.001	.002	3	6
GBM	PPFIBP1 →	+0.391	+0.085	<.001	.001	3	6
LSCC	SRSF3 →	-0.159	-0.120	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0080154 vs PLAT — LSCC

Explore this scatter interactively →