Regulation of fertilization

Across TCGA patient cohorts, RNA activity of the Regulation of fertilization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCR7, GRM3-AS1, and PTPN4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fertilization activity versus CCR7 in BRCA (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CCR7 →	-0.829	-0.597	<.001	.002	3	3
CCRCC	GRM3-AS1 →	+0.267	+0.414	.007	.004	3	3
UCEC	PTPN4 →	+0.387	+0.327	.003	.002	3	3
GBM	RASGRF2 →	+0.761	+0.759	<.001	.001	3	3
UCEC	PRICKLE2 →	+0.556	+0.382	.002	.002	3	3
UCEC	CSRNP3 →	+0.680	+0.381	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0080154 vs CCR7 — BRCA

Explore this scatter interactively →