Intracellular transport of virus

Across TCGA patient cohorts, RNA activity of the Intracellular transport of virus pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A_S1247, COIL_T303, and FMR1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular transport of virus activity versus TOP2A_S1247 in LUAD (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TOP2A_S1247 →	+1.154	+0.078	<.001	<.001	3	7
LUAD	COIL_T303 →	+0.669	+0.067	<.001	<.001	3	6
BRCA	FMR1 →	+0.294	+0.039	<.001	<.001	3	6
LUAD	MCM4_T110 →	+1.100	+0.085	.001	<.001	3	6
LUAD	TPX2_S486 →	+1.067	+0.081	<.001	<.001	3	6
LSCC	HUWE1 →	+0.190	+0.065	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0075733 vs TOP2A_S1247 — LUAD

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