Intracellular transport of virus

Across TCGA pan-cancer cohorts, RNA activity of the Intracellular transport of virus pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 11 member genes.

The strongest signal is observed in kidney chromophobe (KICH), where higher Intracellular transport of virus pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SCLC and READ, show the opposite pattern, with higher activity associated with better survival.

KICH, KIRP, and UCEC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Quartile	II,III,IV	0.412	1.000	<.001	98	view →
KIRP	OS	Quartile	All	0.835	0.962	.001	64	view →
UCEC	DFS	Tertile	All	0.628	0.862	<.001	60	view →
ACC	DFS	Median	All	0.532	0.781	.001	45	view →
SCLC	DFS	Tertile	All	0.551	0.201	<.001	37	view →
READ	DFS	Quartile	III,IV	0.789	0.443	.007	27	view →
UCS	OS	Tertile	II,III,IV	0.685	0.298	.015	24	view →
LIHC	OS	Tertile	III,IV	0.449	0.719	.010	23	view →
LUAD	DFS	Tertile	III,IV	0.848	0.531	.008	15	view →
CESC	DFS	Median	III,IV	0.862	0.595	.013	12	view →
SKCM	DFS	Quartile	All	0.827	0.674	.030	9	view →
LGG	OS	Quartile	All	0.934	0.842	.002	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0075733–KICH (DFS)

Open the KICH breakdown →