Intracellular transport of virus

Across TCGA patient cohorts, RNA activity of the Intracellular transport of virus pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PUS7, SKA3, and TRIP13, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular transport of virus activity versus PUS7 in HNSC (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PUS7 →	+0.693	+0.181	.004	.001	3	6
BRCA	SKA3 →	+0.669	+0.362	<.001	.002	3	6
UCEC	TRIP13 →	+0.830	+0.408	<.001	<.001	3	6
LSCC	CDC45 →	+0.697	+0.508	<.001	<.001	3	6
BRCA	OIP5 →	+0.535	+0.445	<.001	.006	3	5
BRCA	CCNB2 →	+1.004	+0.608	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0075733 vs PUS7 — HNSC

Explore this scatter interactively →