Intracellular transport of virus

Across TCGA cell cohorts, RNA activity of the Intracellular transport of virus pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P3H1, ATP8B3, and ALCAM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, P3H1 grouped by Intracellular transport of virus-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	P3H1 →	-1.071	-0.866	.003	.004	3	4
BREAST	ATP8B3 →	-0.712	-0.678	.009	.007	3	4
LIVER	ALCAM →	+2.026	+1.283	.004	.004	3	4
LUNG_SCLC	MAPK8IP1 →	-2.480	-1.406	.002	.002	3	4
OVARY	CHST3 →	-1.605	-1.054	.003	.001	3	4
OESOPHAGUS	SPOCK1 →	-2.298	-1.173	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

P3H1 by Intracellular transport of virus activity — BREAST

Explore this box plot interactively →