Osteoclast fusion

Across TCGA cell cohorts, RNA activity of the Osteoclast fusion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRAT, ZNF408, and CD9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CRAT grouped by Osteoclast fusion-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CRAT →	+3.313	+1.548	<.001	<.001	3	5
LUNG_NSCLC_LUSC	ZNF408 →	+0.679	+1.614	.002	.004	3	4
LUNG_NSCLC_LUSC	CD9 →	-2.254	-1.640	.008	.003	3	4
LUNG_NSCLC_LUSC	DDR1 →	-2.010	-1.140	.005	.006	3	4
OESOPHAGUS	DMGDH →	+1.709	+0.431	.002	<.001	3	4
OESOPHAGUS	CLIC1 →	-0.820	-0.527	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CRAT by Osteoclast fusion activity — BLOOD_Myeloma

Explore this box plot interactively →