Seminiferous tubule development

Across TCGA patient cohorts, RNA activity of the Seminiferous tubule development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SUPT16H, RFC1_S368, and RFC1_T506, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Seminiferous tubule development activity versus SUPT16H in LSCC (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SUPT16H →	+0.426	+0.091	<.001	<.001	3	8
PDAC	RFC1_S368 →	+0.745	+0.047	<.001	.001	3	7
PDAC	RFC1_T506 →	+1.039	+0.060	<.001	<.001	3	7
HNSC	RFC5 →	+0.362	+0.088	.001	<.001	3	7
LUAD	ZFAND3_S129 →	+0.815	+0.065	.001	.003	3	7
LUAD	FAM76B_T215 →	+0.882	+0.059	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072520 vs SUPT16H — LSCC

Explore this scatter interactively →