Rescue of stalled ribosome

Across TCGA patient cohorts, RNA activity of the Rescue of stalled ribosome pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKT1S1_T246, SRRM1_S389, and PALD1_S406, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Rescue of stalled ribosome activity versus AKT1S1_T246 in BRCA (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AKT1S1_T246 →	+0.801	+0.031	<.001	<.001	3	6
PDAC	SRRM1_S389 →	-0.606	-0.032	<.001	.004	3	5
LSCC	PALD1_S406 →	+0.304	+0.031	.004	.008	3	5
HNSC	MAP4_S853 →	-1.026	-0.098	<.001	.001	3	5
BRCA	NIFK →	-0.268	-0.026	.004	.002	3	5
CCRCC	RPL5 →	-0.192	-0.041	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072344 vs AKT1S1_T246 — BRCA

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