Rescue of stalled ribosome

Across TCGA pan-cancer cohorts, RNA activity of the Rescue of stalled ribosome pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 25 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Rescue of stalled ribosome pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and READ, show the opposite pattern, with higher activity associated with better survival.

KIRC, UCS, and READ are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	II,III,IV	0.370	0.627	.005	74	view →
UCS	DFS	Median	IV	0.952	0.367	.001	40	view →
READ	OS	Tertile	II,III,IV	1.000	0.367	<.001	29	view →
CESC	DFS	Quartile	III,IV	0.244	0.784	.007	20	view →
PRAD	DFS	Median	All	0.954	0.917	.004	18	view →
ACC	DFS	Median	IV	0.570	0.087	.003	17	view →
KICH	OS	Median	All	0.652	0.960	.008	14	view →
SCLC	OS	Median	II,III,IV	0.390	0.978	.004	14	view →
UVM	OS	Tertile	III,IV	0.318	1.000	.021	13	view →
LUAD	DFS	Median	III,IV	0.629	0.399	.032	10	view →
CHOL	DFS	Tertile	All	0.740	0.144	.017	9	view →
DLBC	DFS	Tertile	All	0.555	1.000	.017	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0072344–KIRC (DFS)

Open the KIRC breakdown →