Modified amino acid transport

Across TCGA patient cohorts, RNA activity of the Modified amino acid transport pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CFTR, HSD17B4_S294, and RGN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modified amino acid transport activity versus CFTR in LUAD (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CFTR →	+1.168	+0.045	<.001	.001	3	4
COAD	HSD17B4_S294 →	+0.765	+0.065	<.001	<.001	3	4
PDAC	RGN →	+0.697	+0.045	<.001	<.001	3	4
PDAC	ATAT1_S276 →	-0.495	-0.048	<.001	<.001	3	4
PDAC	SLC4A4_S179 →	+1.423	+0.037	<.001	<.001	3	4
PDAC	SLC4A4_S223 →	+1.423	+0.037	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072337 vs CFTR — LUAD

Explore this scatter interactively →