Modified amino acid transport

Across TCGA pan-cancer cohorts, RNA activity of the Modified amino acid transport pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 50 member genes.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher Modified amino acid transport pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and LUAD, show the opposite pattern, with higher activity associated with better survival.

BLCA, HNSC, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	All	0.402	0.582	<.001	77	view →
HNSC	OS	Median	All	0.228	0.529	<.001	72	view →
ACC	DFS	Tertile	II,III,IV	0.192	0.620	.001	58	view →
LGG	DFS	Median	All	0.267	0.496	<.001	54	view →
THCA	OS	Quartile	All	0.968	0.996	<.001	45	view →
LIHC	DFS	Tertile	All	0.292	0.519	<.001	39	view →
CESC	DFS	Median	IV	0.286	0.671	.010	32	view →
ESCA	OS	Tertile	All	0.489	1.000	.002	21	view →
STAD	DFS	Quartile	III,IV	0.441	0.640	.015	15	view →
READ	DFS	Tertile	II,III,IV	0.965	0.644	.002	15	view →
LUAD	OS	Tertile	All	0.384	0.318	.024	12	view →
KIRP	DFS	Quartile	IV	0.861	0.455	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0072337–BLCA (DFS)

Open the BLCA breakdown →