Monocarboxylic acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Monocarboxylic acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNMT, MCM2, and STEAP4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monocarboxylic acid biosynthetic process activity versus RNMT in UCEC (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNMT →	-0.462	-0.261	.001	<.001	2	6
UCEC	MCM2 →	-1.593	-0.283	.002	<.001	3	5
BRCA	STEAP4 →	+1.309	+0.201	<.001	<.001	3	4
UCEC	SMC4 →	-0.704	-0.297	.001	<.001	3	4
UCEC	ECT2 →	-1.044	-0.332	<.001	<.001	3	4
LSCC	FMO5 →	+1.007	+0.142	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072330 vs RNMT — UCEC

Explore this scatter interactively →