Metanephric nephron development

Across TCGA patient cohorts, RNA activity of the Metanephric nephron development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LRP1, PPFIBP1, and PTK7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric nephron development activity versus LRP1 in LSCC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LRP1 →	+0.457	+0.071	<.001	<.001	3	8
BRCA	PPFIBP1 →	+0.412	+0.036	<.001	.002	3	8
BRCA	PTK7 →	+0.518	+0.049	<.001	<.001	3	7
OV	SFRP2 →	+2.011	+0.077	<.001	<.001	3	7
LSCC	CNN3 →	+0.714	+0.058	<.001	<.001	3	7
LSCC	DENND2B →	+0.549	+0.082	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072210 vs LRP1 — LSCC

Explore this scatter interactively →