Epithelial tube formation

Across TCGA cell cohorts, RNA activity of the Epithelial tube formation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRMT13, SCUBE3, and BEND6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRMT13 grouped by Epithelial tube formation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TRMT13 →	-0.816	-1.340	<.001	.005	2	5
SKIN	SCUBE3 →	-1.734	-0.861	.004	.002	3	3
BLOOD_Myeloma	BEND6 →	-1.241	-1.638	.002	.002	3	3
BLOOD_Myeloma	ZNF441 →	-0.945	-1.355	.004	.004	3	3
SKIN	ACTC1 →	-0.099	-0.964	.007	.001	3	3
SKIN	TFAP4 →	+0.523	+0.941	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRMT13 by Epithelial tube formation activity — BLOOD_Myeloma

Explore this box plot interactively →