Mesonephric tubule formation

Across TCGA patient cohorts, RNA activity of the Mesonephric tubule formation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIX1, SIX4, and SALRNA1, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesonephric tubule formation activity versus SIX1 in BRCA (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SIX1 →	+1.803	+0.090	<.001	<.001	3	20
ESCA	SIX4 →	+1.300	+0.083	<.001	<.001	3	19
THYM	SALRNA1 →	+1.127	+0.064	<.001	<.001	3	19
UCS	RBFOX2 →	+1.182	+0.120	<.001	.001	3	17
ACC	HS2ST1 →	+0.677	+0.067	.003	<.001	2	18
MESO	MAP4K5 →	+0.535	+0.051	.008	.001	2	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072172 vs SIX1 — BRCA

Explore this scatter interactively →