Mesonephric tubule formation

Across TCGA patient cohorts, RNA activity of the Mesonephric tubule formation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SIX1_S204, SIX4, and MSI2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesonephric tubule formation activity versus SIX1_S204 in HNSC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SIX1_S204 →	+1.327	+0.126	<.001	<.001	3	5
LSCC	SIX4 →	+0.531	+0.089	<.001	.001	3	4
HNSC	MSI2 →	+0.253	+0.062	.003	.001	3	4
CCRCC	RFTN1 →	-0.326	-0.096	.001	<.001	3	4
COAD	EHBP1L1 →	-0.169	-0.041	.001	.006	3	4
HNSC	PLCB3_S926 →	-0.373	-0.080	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072172 vs SIX1_S204 — HNSC

Explore this scatter interactively →