Mesonephric tubule formation

Across TCGA patient cohorts, RNA activity of the Mesonephric tubule formation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBX7, MIR4730, and PI3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesonephric tubule formation activity versus CBX7 in BRCA (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CBX7 →	+0.510	+0.570	.004	.004	3	4
CCRCC	MIR4730 →	+0.821	+0.536	.003	<.001	3	4
UCEC	PI3 →	-3.390	-0.250	<.001	<.001	3	4
LSCC	ZNF227 →	+0.258	+0.251	.004	<.001	3	4
BRCA	HECTD2 →	+0.590	+0.487	<.001	<.001	3	4
BRCA	MN1 →	+0.922	+0.718	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072172 vs CBX7 — BRCA

Explore this scatter interactively →