Mesonephric tubule formation

Across TCGA cell cohorts, RNA activity of the Mesonephric tubule formation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIX4, HNF1B, and OSR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SIX4 grouped by Mesonephric tubule formation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SIX4 →	-0.147	-0.527	.001	.001	3	6
LUNG_NSCLC_LUAD	HNF1B →	-0.298	-0.726	<.001	<.001	3	5
OESOPHAGUS	OSR1 →	-0.139	-0.335	.002	.002	3	5
BLOOD_Myeloma	MEOX2 →	-0.316	-1.600	.001	.002	3	4
URINARY_TRACT	SIX1 →	-0.297	-1.549	.006	.008	3	4
URINARY_TRACT	KLRA1P →	+0.206	+1.446	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SIX4 by Mesonephric tubule formation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →