Mesonephric tubule formation

Across TCGA cell cohorts, RNA activity of the Mesonephric tubule formation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COPS8, GAS2L3, and GBP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COPS8 grouped by Mesonephric tubule formation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	COPS8 →	-0.759	-0.248	.001	.009	3	5
URINARY_TRACT	GAS2L3 →	-1.656	-2.257	.005	<.001	3	3
CNS	GBP4 →	-1.186	-0.608	<.001	.009	3	3
CNS	DDN →	+0.691	+0.924	.001	.002	2	4
LUNG_SCLC	FIZ1 →	+0.828	+0.290	.005	.004	3	3
SKIN	PRKD3 →	-1.164	-1.048	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COPS8 by Mesonephric tubule formation activity — BLOOD_Leukemia

Explore this box plot interactively →