Mesonephric tubule formation

Across TCGA cell cohorts, RNA activity of the Mesonephric tubule formation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNAB2, TBX15, and HCAR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNAB2 grouped by Mesonephric tubule formation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	KCNAB2 →	+0.244	+1.746	.007	<.001	3	5
BLOOD_Leukemia	TBX15 →	-0.160	-1.367	<.001	<.001	3	4
BLOOD_Lymphoma	HCAR2 →	+0.193	+1.745	<.001	<.001	2	5
BONE	SPIB →	-0.178	-1.466	.006	<.001	3	4
BLOOD_Myeloma	ANKS1A →	+0.406	+2.084	.005	<.001	3	3
BLOOD_Myeloma	AFM →	+0.105	+1.622	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNAB2 by Mesonephric tubule formation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →